Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
Scientific article available at:
“Virology”
How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Vaccines”
Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Journal of Epidemiology and Global Health”
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“eClinicalMedicine”
The Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf): Risk Factors and Determinants of Immune Response in Healthcare Workers
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
Scientific article available at:
“Viruses”
SARS-CoV-2 Reinfections in Health-Care Workers, 1 March 2020–31 January 2023
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Viruses”
Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
“Pediatrics”
The representative COVID-19 cohort Munich (KoCo19): from the beginning of the pandemic to the Delta virus variant
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
Scientific article available at:
“BMC Infectious Diseases”
Using machine learning to predict antibody response to SARS-CoV-2 vaccination in Solid Organ Transplant Recipients.The multicentre ORCHESTRA cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“Clinical Microbiology and Infection”
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Contributing partner:
French National Institute of Health and Medical Research (INSERM)
Scientific article available at:
“Genome Medicine”
The Effect of the Immunization Schedule and Antibody Levels (Anti-S) on the Risk of SARS-CoV-2 Infection in a Large Cohort of Healthcare Workers in Northern Italy
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“Vaccines”
Diagnostic Accuracy of a Rapid SARS-CoV-2 Antigen Test Among People Experiencing Homelessness: A Prospective Cohort and Implementation Study
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Infectious Diseases and Therapy”
Effect of a Fourth Dose of mRNA Vaccine and of Immunosuppression in Preventing SARS-CoV-2 Breakthrough Infections in Heart Transplant Patients
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“Microorganisms”
Integrative modelling of reported case numbers and seroprevalence reveals time-dependent test efficiency and infectious contacts
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
and Helmholtz Zentrum München (HMGU)
Scientific article available at:
“Epidemics”
Impact of Omicron variant infection on assessment of spike-specific Immune responses using Quan-T-Cell SARS-CoV-2 assay and Roche Elecsys anti-SARS-CoV-2-S
Contributing partner:
Ludwig-Maximilian – Universität München (LMU)
Scientific article available at:
“Pathology and Molecular Diagnostics”
Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments
Contributing partner:
University of Antwerp (UAntwerp)
University of Verona (UNIVR)
Scientific article available at:
“JCI The Journal of Clinical Investigation”
Relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients: the CONTRAST cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“Clinical Infectious Diseases”
SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“J. Clin. Med.”
Temporal trends of COVID-19 antibodies in vaccinated healthcare workers undergoing repeated serological sampling: An individual-level analysis within 13 months in the ORCHESTRA cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“Frontiers in Immunology”
Effectiveness of prevention of SARS-CoV-2 transmission among unvaccinated Italian healthcare workers
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“Med Lav”
Primary SARS-CoV-2 Infections, Re-infections and Vaccine Effectiveness during the Omicron Transmission Period in Healthcare Workers of Trieste and Gorizia (Northeast Italy), 1 December 2021–31 May 2022
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Viruses”
Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron Variant of Concern
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
eLife (elifesciences.org)
SARS-CoV-2 and Its Variants in Thrice-Infected Health Workers: A Case Series from an Italian University Hospital
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Viruses
Retrospective analysis of SARS-CoV-2 omicron invasion over delta in French regions in 2021–22: a status-based multi-variant model
Contributing partner:
French National Institute of Health and Medical Research (INSERM)
Scientific article available at:
“BMC Infectious Diseases”
The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients
Contributing partner:
University Medical Center Groningen (UMCG)
Scientific article available at:
“PLOS ONE”
Predictors of clinical evolution of SARS-CoV-2 infection in hematological patients: A systematic review and meta-analysis
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Hematological Oncology”
Association of Patients’ Epidemiological Characteristics and Comorbidities
with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of
an Umbrella Systematic Review and Meta-Analysis
Contributing partner:
Servicio Andaluz de Salud (SAS)
Scientific article available at:
“Biomedicines”
Perceived Psychological Impact on Children and Parents of Experiencing COVID-19 Infection in One or More Family Members
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
“Children”
Usefulness and Limitations of Anti-S IgG Assay in Detecting Previous SARS-Cov-2 Breakthrough Infection in Fully Vaccinated Healthcare Workers
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Diagnostics”
Clinical Impact of Monoclonal Antibodies in the Treatment of High-Risk Patients with SARS-CoV-2 Breakthrough Infections: The ORCHESTRA Prospective Cohort Study
Contributing partner:
University of Bologna (UNIBO)
Helmholtz Zentrum München (HMGU)
University of Antwerp (UAntwerp)
Scientific article available at:
“Biomedicines”
Challenges of data sharing in European Covid-19 projects: A learning opportunity for advancing pandemic preparedness and response
Contributing partner:
University of Verona (UNIVR)
University Medical Center Groningen (UMCG)
Scientific article available at:
“The Lancet Regional Health – Europe”
SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers
Contributing partner:
University of Bologna (UNIBO)
University of Verona (UNIVR)
Scientific article available at:
“Vaccines”
Exhaustion in Healthcare Workers after the First Three Waves of the COVID-19 Pandemic
Contributing partner:
National Institute of Public Health (INSP)
Scientific article available at:
“International Journal of Environmental Research and Public Health”
Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals
Contributing partner:
The Congolese Foundation for Medical Research (FCRM)
Scientific article available at:
“BMC Infectious Diseases”
Preliminary Evidence on Pulmonary Function after Asymptomatic and Mild COVID-19 in Children
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
“Children”
Clinical efficacy of different monoclonal antibody regimens among non-hospitalised patients with mild to moderate COVID-19 at high risk for disease progression: a prospective cohort study
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“European Journal of Clinical Microbiology & Infectious Diseases”
Harmonization and standardization of data for a pan-European cohort on SARS- CoV-2 pandemic
Contributing partner:
Berlin Institute of Health (BIH/Charité)
Scientific article available at:
“npj Digital Medicine”
Social Isolation Among Older Adults in the Time of COVID-19: A Gender Perspective
Contributing partner:
French national institute of health and medical research (INSERM)
Scientific article available at:
“Frontiers in Public Health”
Trends in social exposure to SARS-Cov-2 in France. Evidence from the national socio-epidemiological cohort–EPICOV
Contributing partner:
French National Institute of Health and Medical Research (INSERM)
Scientific article available at:
“PLOS ONE”
Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“Microorganisms”
Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
“La Medicina del Lavoro, Journal of the Italian Society of Occupational Health”
Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis
Contributing partner:
University of Bologna (UNIBO)
University of Verona (UNIVR)
Servicio Andaluz de Salud (SAS)
Scientific article available at:
“Clinical Microbiology and Infection”
Risk and severity of SARS-CoV-2 infection in breast cancer patients undergoing a structured infection screening program at the University and Hospital Trust of Verona
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Annals of Oncology”
Protective SARS-CoV-2 Antibody Response in Children With Inflammatory Bowel Disease
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
“Frontiers in Pediatrics”
Determinants of persistence of symptoms and impact on physical and mental wellbeing in Long COVID: A prospective cohort study
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
“Journal of Infection”
Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich – One year of experience
Contributing partner:
Ludwig-Maximilian- Universität München (LMU)
Scientific article available at:
“Science of The Total Environment”
Seroepidemiology and model-based prediction of SARS-CoV-2 in Ethiopia: longitudinal cohort study among front-line hospital workers and communities
Contributing partner:
Ludwig-Maximilian – Universität München (LMU)
and Helmholtz Zentrum München (HMGU)
Scientific article available at:
“The Lancet Global Health”
ORCHESTRA project in Romania – a prospective occupational cohort to study the impact of COVID-19 pandemic on healthcare workers
Contributing partner:
National Institute of Public Health (INSP)
Scientific article available at:
“Romanian Journal of Occupational Medicine”
From first to second wave: follow-up of the prospective Covid-19 cohort (KoCo19) in Munich (Germany)
Contributing partner:
Ludwig-Maximilian- Universität München (LMU)
Scientific article available at:
“BMC infectious diseases”
Mild SARS-CoV-2 Infections and Neutralizing Antibody Titers
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
“PEDIATRICS®”
A dried blood spot protocol for high throughput analysis of SARS-CoV-2 serology based on the Roche Elecsys anti-N assay
Contributing partner:
Ludwig-Maximilian – Universität München (LMU)
Scientific article available at:
“eBioMedicine”
Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay
Contributing partner:
Ludwig-Maximilian- Universität München (LMU)
Scientific article available at:
“Frontiers in Immunology”
Left ventricle longitudinal strain alterations in asymptomatic or mildly symptomatic pediatric patients with recent SARS-CoV-2 infection
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
“European Heart Journal – Cardiovascular Imaging”
The following overview shows all deliverables approved to date.
The public deliverables can be downloaded.
Del Rel. No | Title | Lead Beneficiary | Dissemination level and availability |
D1.1 | Project Management Guidelines | UNIVR | Download |
D1.2 | Revised project plan following kick off meeting | UNIVR | Confidential |
D1.3 | Database for Ethics Approval | UNIVR | Confidential |
D1.5 | Interim activity report | UNIVR | Confidential |
D1.6 | Ethics Board Report Interim | UNIVR | Confidential |
D2.1 | Systematic review of the literature on determinants of COVID-19 manifestation/ progression | SAS | Download |
D2.5 | Final report of 6-month follow up by clinical, immunological and virological features | UNIVR | Download |
D3.1 | Guiding principles report on type and source of population cohorts | INSERM | Confidential |
D3.2 | Preliminary report on seroprevalence in EU countries | INSERM | Download |
D4.1 | Report on ORCHESTRA-fragile population | UNIBO | Confidential |
D4.2 | Protocol for prospective cohort of vaccinated and non vaccinated fragile patients | UNIBO | Confidential |
D4.3 | Quality and kinetic of early immune response to COVID-19 vaccination in fragile patients | UNIBO | Download |
D5.5 | Interim analysis of serology results after vaccination | UNIBO | Download |
D5.6 | Immunological response in vaccinated and not vaccinated HCWs (temporal trend) final | UNIBO | Download |
D5.7 | First interim risk analysis of breakthrough infection | LMU MUENCHEN | Download |
D5.8 | Incidence of breakthrough infections | LMU MUENCHEN | Download |
D5.10 | Final analysis of serology results after vaccination | UNIBO | Download |
D6.1 | Standardised protocol and manual on collection and storage of samples | UANTWERPEN | Confidential |
D6.2 | Dataset of human genome sequencing of patients with COVID-19 from retrospective cohorts | UNIBO | Download |
D6.3 | Report on viral loads, viral genome sequences of retrospective cohorts | INSERM | Download |
D6.4 | Report on serology analysis of retrospective COVID-19 cohorts | INSERM | Download |
D6.5 | Report on cytokine chemokine analysis in COVID-19 patients from retrospective cohorts | UANTWERPEN | Download |
D6.6 | First report on serology in fragile populations | INSERM | Download |
D6.7 | First report on immunity analysis from prospective cohorts (COVID-19, vaccinated and not vaccinated) | UANTWERPEN | Download |
D6.8 | Report on viral loads, viral genome sequences on prospective cohorts (preliminary report) | INSERM | Download |
D6.10 | Dataset of 16S rRNA sequencing of retrospective cohorts | UNIBO | Download |
D7.1 | Data Management Plan | CINES | Confidential |
D7.3 | First version of report on Data Protection and Access Policy | Charité | Confidential |
D7.4 | Report on feasibility assessment of statistical analysis within modelling workflow | CINES | Confidential |
D7.6 | First report on ORCHESTRA portal: a preliminary prototype with reduced functionalities required for non sensitive data. Second, intermediate report on ORCHESTRA portal. Final report on ORCHESTRA portal | CINECA | Confidential |
D8.1 | Report on estimates of intervention effects using compartment model | HMGU | Download |
D8.7 | In silico model of vaccination strategies | HMGU | Download |
D9.1 | Working plan | UMCG | Confidential |
D9.2 | Protocol Evaluation Framework | UMCG | Confidential |
D9.3 | Consortium agreement with new Cohorts | UMCG | Confidential |
D10.1 | Communication and dissemination strategy plan and website online | UHC | Download |
D10.2 | Social media accounts created and accredited | UHC | Download |
D10.3 | First regular graphics visualized | UHC | Download |
D10.4 | Anonymous dataset for the public published | UHC | Download |
D10.5 | Call for first science challenge based on anonymized project dataset | UHC | Download |
D10.6 | Cohort Builder and Dashboard online | UHC | Download |
D10.7 | Automated emails service for stakeholders | UHC | Download |
D11.1 | H – Requirement No. 1 | UNIVR | Confidential |
D11.3 | HCT – Requirement No. 3 | UNIVR | Confidential |
D11.4 | HCT – Requirement No. 4 | UNIVR | Confidential |
D11.5 | POPD – Requirement No. 6 | UNIVR | Confidential |
D11.6 | NEC – Requirement No. 7 | UNIVR | Confidential |
Acknowledgements
ORCHESTRA has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016167. [Long version]
***
Supported by the H2020-RIA GA No 101016167. [Short version]
***
All publications of research results or information from EU-funded projects must be clearly marked with the EU-emblem (EU-flag) and information about the financial funding mechanism.
You need to acknowledge the EU-funding when:
writing articles in newspapers, journals
being interviewed e.g. for a newspaper, journal, radio, tv programme
producing printed material such as brochures/leaflets/posters
having presentations in public fora, e.g. conferences, seminars
For more information, please consult the ORCHESTRA Publication Policy, available upon request: pmu@orchestra-cohort.eu
Disclaimer clause
The views expressed in this [publication/document/paper…] are the sole responsibility of the author and the Commission is not responsible for any use that may be made of the information it contains.